Conclusions about vitamin D in CPPS

As vitamin D is a strong immuno-regulatory hormone(1) and has been proven effective for treating conditions, like musculoskeletal pain, there is reason to believe low D-levels, even if not causative, may exacerbate CP/CPPS. The findings above do also suggest why prostaglandin inhibitors are effective in treating CPPS, and why symptoms go in remission during summer.

This also lends support to the hypothesis that CP/CPPS has a neuromuscular/myofascial component. Cold and freezing may cause muscular tension. D-vitamin deficiency is implicated in myopathies, as are calcium and magnesium deficiencies, and depression (SAD).(2)

As Melatonin enhances cellular immunity and cold has an effect on at least some of the components involved in immunity this may also be a cause of winter-time flares, especially when bodily levels of D3 are low.

Andra bloggar om CPPS, kroniskt bäckenbottensmärtsyndrom, kronisk abakteriell prostatit, NIHIIIb, överaktiv blåsa, värme, sommar, D-vitamin, inkontinens.
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(1) Hewison M. Vitamin D and the intracrinology of innate immunity. Mol Cell Endocrinol 321(2):103-11, 2010.
(2) Verstuyf A, Carmeliet G, Bouillon R, Mathieu C. Vitamin D: a pleiotropic hormone. Kidney Int. 2010 Feb 24. Epub ahead of print

Temporary pause due to RL

Sorry for posting nothing in the last month, but professional commitments in RL keeps me currently very busy.