Not much research has been done. There is a study showing an association between a "highly polymorphic short tandem repeat (STR) locus near the phosphoglycerate kinase gene within Xq11-13" (1) and another indicating low TNF-alpha (NIH-IIIa) or low IL-10 expression (NIH-III).(2) A newer study showed differences in manganese superoxide dismutase and gluthathione polymorphisms versus controls.(3)
A general discussion on genetic research in CPPS and IC is given by Dimitrakov and Guthrie.(4)
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(1) Riley DE, Krieger JN. X Chromosomal short tandem repeat polymorphisms near the phosphoglycerate kinase gene in men with chronic prostatitis. Biochim Biophys Acta 1586(1):99-107, 2002.
(2) Shoskes DA, Albakri Q, Thomas K, Cook D. Cytokine polymorphisms in men with chronic prostatitis/chronic pelvic pain syndrome: association with diagnosis and treatment response. J Urol. 168(1):331-335, 2002.
(3) Arisan ED, Arisan S, Kiremit MC, Tiğli H, Caşkurlu T, Palavan-Unsal N, Ergenekon E. Manganese superoxide dismutase polymorphism in chronic pelvic pain syndrome patients. Prostate Cancer Prostatic Dis. 9(4):426-431, 2006.
(4) Dimitrakov J, Guthrie D. Genetics and phenotyping of urological chronic pelvic pain syndrome. J Urol 181(4):1550-1557, 2009.
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