Friday, November 27, 2009

Does testosterone cause prostate cancer?

A very good question and not likely related to CPPS, but there is a dicussion if there is a correlation. The association between testosterone and cancer is currently in doubt due to the following. Men dying from prostate cancer are all castrated (zero testosterone) due to treatment. Huggins assertion that testosterone causes cancer is based on equivocal results from one patient!! No modern studies during the last 25 years have managed to prove that prostate cancer cells grow with extra testosterone.(1) Prostate cancer increases with age, while testosterone decrease with age. Aggressive cancer is correlated with low testosterone.(2) As is recurrence. Morgentaler calls the high testosterone cancer connection a myth.(3) Recent research indicates that vitamin D deficiency may increase the risk of developing prostate cancer.(4)

Andra bloggar om , , ,
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(1) Endogenous Hormones and Prostate Cancer Collaborative Group, Roddam AW, Allen NE, Appleby P, Key TJ. Endogenous sex hormones and prostate cancer: a collaborative analysis of 18 prospective studies. JNCI 100(3):170-183, 2008.
(2) C Schulman, Testosteron treatment and and prostate risk, EUA Congress 2009
(3) Morgentaler A. Testosterone and prostate cancer: an historical perspective on a modern myth. Eur Urol 50(5):935-939, 2006.
(4) Schwartz GG. Vitamin D and intervention trials in prostate cancer: from theory to therapy. Ann Epidemiol. 19(2):96-102, 2009.

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