Sunday, March 1, 2009

Pituitary symptom cluster

This is a tentative cluster. It is based on anecdotal evidence, facets of urinary and sickness behaviour symptoms, and foods reported to exacerbate symptoms. (The pituitary is also called hypophysis.)

Possibly pituitary / HPA-axis related problems
• Problems with vasopressin regulation. This is indicated by increased susceptibility to vasopressin antagonists. E.g. worsening of nocturia, diuresis and urgency after alcohol and caffeine intake. (I.e. symptoms showing a similarity with diabetes insipidus.)

• Sleep disruption (nocturia-caused or not?)

• Abrupt mood fluctuations (irritability, aggression and anger).

• Sudden feelings axiety with no obvious cause.

• Cold sweats. Similar to night sweats. Body temperature regulation. Anecdotal.

• Depression.

• Fatigue.

• Leg weakness.

• Lower than average bone density.

• Decreased / low libido. (Added march 4th 2009)

Possibly thyroid related problems
These symptoms may be caused by hypothyroidism. And yes there is a point in mentioning those with pituitary/HPA problems as pituitary regulation problems may cause secondary hypothyroidism.

• “Uncontrollable” nightly sweating / hot flashes. Indicates problems with body temperature regulation. Anecdotal.

• Cold sweats. Similar to night sweats. Body temperature regulation. Anecdotal.

• Feeling unfocused / not alert.

• Fatigue.

• Constipation.

• Feeling cold.

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Further reading
Sievers C, Ising M, Pfister H, Dimopoulou C, Schneider H, Roemmler J, Schopohl J, Stalla G. Personality in patients with pituitary adenomas is characterized by increased anxiety related traits: comparison of 70 acromegalic patients to patients with non-functioning pituitary adenomas and age- and gender matched controls. Europ J Endocrin 160:367, 2009.

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