Calcium, cancer and pituitary
Can rising parathyroid hormone concentrations or changed calcium metabolism / homeostasis with decreasing D-vitamin levels trigger CP/CPPS or some of its symptoms? Maybe, as vitamin D and “calcium malnutrition eventually causes a decrease in calcium concentration in extracellular fluid compartments, resulting in organ-specific… attenuation of signal transduction from the ligand-activated vitamin D receptor and calcium-sensing receptor” causing “perturbation of cellular functions in bone, kidney, intestine, mammary and prostate glands, endocrine pancreas, vascular endothelium, and, importantly, in the immune system.”(1) Calcium deficiency may also promote breast, prostate and colorectal cancer. Adequate calcium levels may also regulate Th1 (cellular) immune response.
It is interesting that the vitamin D receptor (VDR) is present in the pituitary, which is central in diuretic and prostaglandin regulation. Especially as there are many indications of pituitary dysfunction in CPPS sufferers.
Nutritional adequacy
More or less everyone living north of the 60th parallel will have insufficient levels of vitamin D or out-right deficiency by the end of winter. This is because there is not enough sunlight from November to March. This is also exacerbated by indoors living and clothing during the summer months.
Andra bloggar om CPPS, kroniskt bäckenbottensmärtsyndrom, kronisk abakteriell prostatit, NIHIIIb, överaktiv blåsa, köld, värme, vinter, sommar, D-vitamin, auto-immun sjukdom, Th1/Th2.
___________________
(1) Peterlik M, Cross HS. Vitamin D and calcium deficits predispose for multiple chronic diseases. Eur J Clin Invest 35(5):290-304, 2005.
Subscribe to:
Post Comments (Atom)
No comments:
Post a Comment