Tuesday, February 17, 2009

Sickness behaviour symptom cluster

A combination of symptoms generally found after immune activation regardless of source (viral, bacterial, fungal, protozoal, pain, tissue damage etc). Clinically often noticed. Has been studied in cancer treatment. All these symptoms/signs can be regarded as indicative for CPPS-sufferers as they often wax and wane during the course of the illness, while no other obvious source can be found. Actually CPPS has been reported to occasionally go in remission when a CPPS sufferer falls ill in the flu, or catches a cold etc.

Notice that some of the symptoms below are more or less synonyms (anhedonia and depression; fatigue, asthenia, sleepiness and tiredness).

• Malaise: “A feeling of general discomfort or uneasiness, an 'out-of-sorts' feeling...” (From Stedman’s.)

• Fatigue: “…a lessened capacity for work and reduced efficiency of accomplishment, usually accompanied by a feeling of weariness, sleepiness, or irritability; may also supervene when, from any cause, energy expenditure outstrips restorative processes…” (From Stedman’s.)

• Asthenia: weakness, “lack of motor activity or strength”.

• Tiredness / sleepiness.

• Depression / dejection (lessened interest in other people, withdrawal etc). It may be noted that a subgroup of clinically depressed people have excess levels of (pro-) inflammatory mediators (substances).

• Anhedonia / listlessness (“…sensation of boredom and lassitude due to absence of stimulation, monotony, or lack of interest in one's surroundings.” From Stedman’s.)

• Lessened hunger / difficulty putting on weight (“anorexia”).

• Anxiety (withdrawal, feeling uncomfortable / nervous in public places or social situations, “paranoia”) etc..

• Irritability normally co-occuring with fatigue / tiredness etc, but may also occur for no obvious reason.

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